	   SnapGene      ´ACTCGTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTACTAGTACGTCTCTCAAGGATAAGTAAGTAATATTAAGGTACGGGAGGTATTGGACAGGCCGCAATAAAATATCTTTATTTTCATTACATCTGTGTGTTGGTTTTTTGTGTGAATCGATAGTACTAACATACGCTCTCCATCAAAACAAAACGAAACAAAACAAACTAGCAAAATAGGCTGTCCCCAGTGCAAGTGCAGGTGCCAGAACATTTCTCTGGCCTAACTGGCCGGTACCTGAGCTCTGAGTTCTCACGCTAGCAGATTGAGTTCTCACGCTAGCAGATTGAGTTCTCACGCTAGCAGATCTCGAGGATATCAAGATCTGGCCTCGGCGGCCAAGCTTAGACACTAGAGGGTATATAATGGAAGCTCGACTTCCAGCTTGGCAATCCGGTACTGTTGGTAAAGCCACCATGGAAGATGCCAAAAACATTAAGAAGGGCCCAGCGCCATTCTACCCACTCGAAGACGGGACCGCCGGCGAGCAGCTGCACAAAGCCATGAAGCGCTACGCCCTGGTGCCCGGCACCATCGCCTTTACCGACGCACATATCGAGGTGGACATTACCTACGCCGAGTACTTCGAGATGAGCGTTCGGCTGGCAGAAGCTATGAAGCGCTATGGGCTGAATACAAACCATCGGATCGTGGTGTGCAGCGAGAATAGCTTGCAGTTCTTCATGCCCGTGTTGGGTGCCCTGTTCATCGGTGTGGCTGTGGCCCCAGCTAACGACATCTACAACGAGCGCGAGCTGCTGAACAGCATGGGCATCAGCCAGCCCACCGTCGTATTCGTGAGCAAGAAAGGGCTGCAAAAGATCCTCAACGTGCAAAAGAAGCTACCGATCATACAAAAGATCATCATCATGGATAGCAAGACCGACTACCAGGGCTTCCAAAGCATGTACACCTTCGTGACTTCCCATTTGCCACCCGGCTTCAACGAGTACGACTTCGTGCCCGAGAGCTTCGACCGGGACAAAACCATCGCCCTGATCATGAACAGTAGTGGCAGTACCGGATTGCCCAAGGGCGTAGCCCTACCGCACCGCACCGCTTGTGTCCGATTCAGTCATGCCCGCGACCCCATCTTCGGCAACCAGATCATCCCCGACACCGCTATCCTCAGCGTGGTGCCATTTCACCACGGCTTCGGCATGTTCACCACGCTGGGCTACTTGATCTGCGGCTTTCGGGTCGTGCTCATGTACCGCTTCGAGGAGGAGCTATTCTTGCGCAGCTTGCAAGACTATAAGATTCAATCTGCCCTGCTGGTGCCCACACTATTTAGCTTCTTCGCTAAGAGCACTCTCATCGACAAGTACGACCTAAGCAACTTGCACGAGATCGCCAGCGGCGGGGCGCCGCTCAGCAAGGAGGTAGGTGAGGCCGTGGCCAAACGCTTCCACCTACCAGGCATCCGCCAGGGCTACGGCCTGACAGAAACAACCAGCGCCATTCTGATCACCCCCGAAGGGGACGACAAGCCTGGCGCAGTAGGCAAGGTGGTGCCCTTCTTCGAGGCTAAGGTGGTGGACTTGGACACCGGTAAGACACTGGGTGTGAACCAGCGCGGCGAGCTGTGCGTCCGTGGCCCCATGATCATGAGCGGCTACGTTAACAACCCCGAGGCTACAAACGCTCTCATCGACAAGGACGGCTGGCTGCACAGCGGCGACATCGCCTACTGGGACGAGGACGAGCACTTCTTCATCGTGGACCGGCTGAAGAGCCTGATCAAATACAAGGGCTACCAGGTAGCCCCAGCCGAACTGGAGAGCATCCTGCTGCAACACCCCAACATCTTCGACGCCGGGGTCGCCGGCCTGCCCGACGACGATGCCGGCGAGCTGCCCGCCGCAGTCGTCGTGCTGGAACACGGTAAAACCATGACCGAGAAGGAGATCGTGGACTATGTGGCCAGCCAGGTTACAACCGCCAAGAAGCTGCGCGGTGGTGTTGTGTTCGTGGACGAGGTGCCTAAAGGACTGACCGGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGCAAGATCGCCGTGAATTCTCACGGCTTCCCTCCCGAGGTGGAGGAGCAGGCCGCCGGCACCCTGCCCATGAGCTGCGCCCAGGAGAGCGGCATGGATAGACACCCTGCTGCTTGCGCCAGCGCCAGGATCAACGTCTAAGGCCGCGACTCTAGAGTCGGGGCGGCCGGCCGCTTCGAGCAGACATGATAAGATACATTGATGAGTTTGGACAAACCACAACTAGAATGCAGTGAAAAAAATGCTTTATTTGTGAAATTTGTGATGCTATTGCTTTATTTGTAACCATTATAAGCTGCAATAAACAAGTTAACAACAACAATTGCATTCATTTTATGTTTCAGGTTCAGGGGGAGGTGTGGGAGGTTTTTTAAAGCAAGTAAAACCTCTACAAATGTGGTAAAATCGATAAGGATCCGTTTGCGTATTGGGCGCTCTTCCGCTGATCTGCGCAGCACCATGGCCTGAAATAACCTCTGAAAGAGGAACTTGGTTAGCTACCTTCTGAGGCGGAAAGAACCAGCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCGATTCTTCTGACACTAGCGCCACCATGAAGAAGCCCGAACTCACCGCTACCAGCGTTGAAAAATTTCTCATCGAGAAGTTCGACAGTGTGAGCGACCTGATGCAGTTGTCGGAGGGCGAAGAGAGCCGAGCCTTCAGCTTCGATGTCGGCGGACGCGGCTATGTACTGCGGGTGAATAGCTGCGCTGATGGCTTCTACAAAGACCGCTACGTGTACCGCCACTTCGCCAGCGCTGCACTACCCATCCCCGAAGTGTTGGACATCGGCGAGTTCAGCGAGAGCCTGACATACTGCATCAGTAGACGCGCCCAAGGCGTTACTCTCCAAGACCTCCCCGAAACAGAGCTGCCTGCTGTGTTACAGCCTGTCGCCGAAGCTATGGATGCTATTGCCGCCGCCGACCTCAGTCAAACCAGCGGCTTCGGCCCATTCGGGCCCCAAGGCATCGGCCAGTACACAACCTGGCGGGATTTCATTTGCGCCATTGCTGATCCCCATGTCTACCACTGGCAGACCGTGATGGACGACACCGTGTCCGCCAGCGTAGCTCAAGCCCTGGACGAACTGATGCTGTGGGCCGAAGACTGTCCCGAGGTGCGCCACCTCGTCCATGCCGACTTCGGCAGCAACAACGTCCTGACCGACAACGGCCGCATCACCGCCGTAATCGACTGGTCCGAAGCTATGTTCGGGGACAGTCAGTACGAGGTGGCCAACATCTTCTTCTGGCGGCCCTGGCTGGCTTGCATGGAGCAGCAGACTCGCTACTTCGAGCGCCGGCATCCCGAGCTGGCCGGCAGCCCTCGTCTGCGAGCCTACATGCTGCGCATCGGCCTGGATCAGCTCTACCAGAGCCTCGTGGACGGCAACTTCGACGATGCTGCCTGGGCTCAAGGCCGCTGCGATGCCATCGTCCGCAGCGGGGCCGGCACCGTCGGTCGCACACAAATCGCTCGCCGGAGCGCAGCCGTATGGACCGACGGCTGCGTCGAGGTGCTGGCCGACAGCGGCAACCGCCGGCCCAGTACACGACCGCGCGCTAAGGAGGTAGGTCGAGTTTAAACTCTAGAACCGGTCATGGCCGCAATAAAATATCTTTATTTTCATTACATCTGTGTGTTGGTTTTTTGTGTGTTCGAACTAGATGCTGTCGACCGATGCCCTTGAGAGCCTTCAACCCAGTCAGCTCCTTCCGGTGGGCGCGGGGCATGACTATCGTCGCCGCACTTATGACTGTCTTCTTTATCATGCAACTCGTAGGACAGGTGCCGGCAGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGCGGCCGCAAATGCTAAACCACTGCAGTGGTTACCAGTGCTTGATCAGTGAGGCACCGATCTCAGCGATCTGCCTATTTCGTTCGTCCATAGTGGCCTGACTCCCCGTCGTGTAGATCACTACGATTCGTGAGGGCTTACCATCAGGCCCCAGCGCAGCAATGATGCCGCGAGAGCCGCGTTCACCGGCCCCCGATTTGTCAGCAATGAACCAGCCAGCAGGGAGGGCCGAGCGAAGAAGTGGTCCTGCTACTTTGTCCGCCTCCATCCAGTCTATGAGCTGCTGTCGTGATGCTAGAGTAAGAAGTTCGCCAGTGAGTAGTTTCCGAAGAGTTGTGGCCATTGCTACTGGCATCGTGGTATCACGCTCGTCGTTCGGTATGGCTTCGTTCAACTCTGGTTCCCAGCGGTCAAGCCGGGTCACATGATCACCCATATTATGAAGAAATGCAGTCAGCTCCTTAGGGCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCGGTGTTGTCGCTCATGGTAATGGCAGCACTACACAATTCTCTTACCGTCATGCCATCCGTAAGATGCTTTTCCGTGACCGGCGAGTACTCAACCAAGTCGTTTTGTGAGTAGTGTATACGGCGACCAAGCTGCTCTTGCCCGGCGTCTATACGGGACAACACCGCGCCACATAGCAGTACTTTGAAAGTGCTCATCATCGGGAATCGTTCTTCGGGGCGGAAAGACTCAAGGATCTTGCCGCTATTGAGATCCAGTTCGATATAGCCCACTCTTGCACCCAGTTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCGGGGTGTGCAAAAACAGGCAAGCAAAATGCCGCAAAGAAGGGAATGAGTGCGACACGAAAATGTTGGATGCTCAT  5i                           "                  %   0   !         '   '      
               $               %                                          
               $   +   (         3   #      "   1   &      +            !                           $   *   (         (            ,               	                                                                                                       '   !                  $               "   
                  !         
                     
                                                   $      '                  "                                             	      5   )         $      	               +   2             :   #   #         !   
      )                         )                         .      #            %      7   2      "                     "      !         xí@É‡	ˆ	@'Aò¦ÿh S  ùîÃ‰	’	`AóðËÂñ� $ ‹ÝÔ@AJ
7§Øi á™(P£0½y¼ý&Ê×	ÿ>Ì(;B8¼  T íð‰–SV}Š	“	gsü{L¡ –É{
)
9
P
˜
þ#©ñ&·ò� : `¬Ž%‰©Æ	
aÒôÖ¯†Ìç© ] Yúï(. ÄÊßŸÛëüû$�—»Bê[y‹Ã" ï /V³Þí–#�
"%AÊÍáP�	K
“
8ßQn8~z ÉßY*j N W Œ²»Œ5‚¸	¤ÄÙiƒ¨¾2S�°9 % Œ ±�	–	
ïá\TÅ ÕB/6¨¿¯&¨Ó/)ÏÙ t	1uzüP³^'ËØ	&
 !–Æ]e<½Ö<}œùÆy¡· ª6ƒ)p¬±ô*c„h
°
GŠû˜©î-~C„›Ak•?x% Ù šòQ¤Ñ¦¾Í½tˆ¤¨äþB\
¤
j|*K/nrc·J9í½µ0 b nwâø•›ÃbI¨\·ÎÒ÷	<Bv5?MÍTh¥Í)tˆÅ0â:•Éòˆ$! U ^‰TëîŠ“†ÈßNT‹	”	
$
:@ehtýÝOl¢x¼iº r½ìi‘—~Ö¢Ùâ  2GiÚÄõ™¬xÒ-%`s�|”•' wFîñASpÎëaWq€ÛRç¤ä|‘ ¹áMÀ[¸äL'  —ÊÞú ‡�mêè“À#l
´
]¨«Ø‡Ñ4ªòÚ÷�!$f~ðŒ Á LÌ	(	ü	
*
Q
™
ÇÞÿ€'~¼óá 
 ˜ ž¿8	:
;ìó‘ ö F|
.
²¿ºÿ$Eú¸ ÍtXò1	ðH”ÄúÚYhª ; � a�ŠåêÁ	õ•×, .C&SŽb°sÍÛ³ù$ Xi­[v‚xÆkàjñ™/ªÇ	æ	wÓ<‡’šèôbqzªá"F ýHð¡ÅË:RUÜý%»˜¼ë÷`Xk­ ^ ‚Zû‚NÈó/:›¶Žàü—ß�ª›Cxz‡ˆ4Ä› ž›¾à	) ì½#Ôõ+„H]¡Œ�š	 —õdWà�ðëWÕŽ\”ÆWu¤% W±ðö”™#&`Ý�¦ËÙQ�	¶	7
N
–
ÊRè9{÷ÝàZµR“'†› – D¼‘D6	&	/	cå9’	g¸Wqs’ … ‡ ” ´ØîMBÎÓŽ	>
@
L
”
ã`Šð¡èê÷ù!=¥+™k ä ê ð 0¶ßeæ—Ù$Xvâàoµ?Ê\åm— 4�`¸­¥v#Ã3T§u– @ D ¼6ƒC	¥	¹	%Ú)j„©'b:d X �>Ò	o
·
WÅ¿ÿž±› - O ¡ ³k²Ü áS0bRKŽ~Ú ‰ ¸ÚÐùÄöŒì6/ƒ!-C¦ & z²^	
F
ÉòâÆU � ÷{	—	Ì	®ð?Ÿ]ex�c 4I{Ëæ±Õ‚	Û›<û³Á*NÔˆëi¬»Æø( ;ÖCpsÆùü37i©O°'¢T©0Š YB
ˆ
Ð
$GÀ+tÔþÐÚûX
 1 ±€³as©0Fº  Ý O\U
�
Ý
£Øì0ÞzŒ*7 uËsvNr±È(‚Ì'
"(5-^f%|?»Â×ÇW8Í( 
»bQ´_»é— ·¾~ºxàz¢™ y2’ZÐ	ÂÇ«g4=�õé¸a$ è#’ü{ÖýLÆv�£Ù	ë	žCs¾lâ“ÆO˜š=ˆ©·ú^yÐÍ+ ì +@U„¸ÈþÿmYÝ	í	e
i
­
±
7ó‹ü~�ª"Q…ûœŸµmp{OÒø@×( f Ñ æ «HUg“q^…'õ+S	¡	s
Œ
»
Ô
ƒÿïÉoBi>Õoy}‡  $*®­²…n	x
|
À
Ä
²Hw™ÈD]–N 7K?DCe¬Ðdð	x.:UAlC<3 Ú €›óRº U¥©å$cxÃs–P	ã	4
 @EuæítÇo¢Ãýdq¦¸95:[PNQª# '<Q%Š”ÿpˆ¿ó<¾u‰ÿ4	
T»+[7‰œÌîD/\� }¦Ä¥ÒðI§Îæ4£C™Ö	:	k}L0s’Ïü^¾¶k" ­ šÛ€’Û	]
¥
Š°ØE/Šš«ËKn­¹.6°¥ÿ3­ç­1 c f}–=F[j3]`¸ÏÓ=C
ÿÎò"•¦*ITu…ÆR�1Ì;ÝæÕ%„& ò xÁÐê0Ê™oœ¸Ø©­»Ÿ¥ goNn§äU•¢m‰]Ï o?Äø¼íJäø	FLw¦éø»Îã â`ã–;	+ ã*2Ôáù4è*7^&c
Nf kxâ
î
÷
®À6@¶i­‰PSÊó³2 # ŠàO¢/»ìü%†	I
þñÊ»Ž 9 _ìïˆŸÉ•êU|¨Å	
f xý"Š®…æ M V î U‹�	!°àO€	Œ	•	’
ÞPm£§}y%½! a Ø ”°‡[¶%
[
g
£
¯
;Aiu{ÅFÕ/I›ÅjÈw ˆí@êÃ
9£ãàw·Ñ,ã_€ õ Ý†¾KlË’¿"
	-
k
³
\ª×¹ëöù}Ž#eò‹ -BWhÌsZ�wj˜.é”r‘Úó©g! �ü–9�ßVºÔ�Óƒ‡ ã é 	bâ‰Ü´Q[f’&p˜ä– , ? C   jÛR¤	n
¶
_·QJ�þ&at}•Ù 3HÊøö]	E
Úõš­Ó.
hw‚ 'B XoÅT
‡
œ
Ï
Ü
#F*syEú‰$ ç"x‘º‘rÕKq°�¢�ÁèrŸ,ª’$N{‡Áô¹V7wÏÌ`*  Ð *?T#G’­B]„ÏXÜ 	ï	d
w
‹
¬
¿
Ó
þ}€\ž´loÔBÖM|( |™¥‰Ãþoïò 3TbÂrO	
3
S‰?å¯6¡×.Ê¬45Mþ© À/36÷ì	¬­	¥÷µ¬ºâSR¡åÔ1 8 L ßN.‡ë žû”é$µÄ	ÄE
ŸÔ.„Éå�( gËÜûJYk€•?8é¾!-è

,
©UÓÒ“†ø+��"dñfŠ > B è Q÷\	£	S
m
›
µ
^ÙˆrÛ	%gˆã  {˜¿!ˆ�n¬\öÁN	Ÿ	v
¾
ˆ¬´5«ó3kÓ¨{ ¾MXj«èž		
+
R
u
š
½
‡TÓ -’*ƒäâ‰, k · ¼ Æ Ó ÓÔWi~þ…				§	»	…†ÈÉÎ+,de()€�‚½âãqr¡ l Ô õ	)	²	¼	ý	Ê@Ïfý@ô€¢ ¸ ½ Â Ç Ë Õ¤ÿŸÍŽ†ÿX	¨	ß'²�DH¾)Gs “		³	;
A×õ<�’£  F h m Õ ŸÀöU	þ	<ËÐÜ	 9*	j	ƒ
Ë
'ËþL ™ ­½	'Aígô ¾ b× �®ø¹ ¦ ¹ Ã È ÷ Ö Î})1}Y	a	d	g	àX«ûEÇt Ì `	
è
ý
³Àñ³ qlç¿*¿ ¥ sÑG€‡· 	E	©	
/
Ž
Ö
(X�»%%‚F~IH„ ”Ç—&Œ‡õ	I•yYÃ³7= u�hn‹oãó¦F[×#ØJßî“ °¯ß¤y	´	<
.~:Á¤ ÎÒ\Y		2	q
z
¹
Â
5ñÅðÁûmBÛZö[i‚« ž Ö Á�‹Ú
=G�Ô/ < i ‘æL	V	Â	ÿ	Ìö�  G n b�OÑ!é- ©  z÷ë­Ý–Ø�¾  Z /D'ï7	k	Ô	qŒ  I | Ù]I	„
Ì
ß±tÜÿë  v ú Æœ/"	+	?	t	(1ÌchÙÎƒú í@TöÛ:p	W�:´M š <Q©®êKl˜¹Úš0¾	Ó“J(ÊBLhp’˜îõ   ´ d,wƒ†‰yákò«´ÔjÇî_ßc«Å âë p � YjjÇ4ç	~
Æ
[Óäˆ›ér{GP ®\|‹´	È	ò
�x›åe=“õA`# Q þ¤Á¢€@ìaßë¤ŸÀ ¿ ØÞUgñÆÌSVÝ™½Mø’YC‹º±ž / cx¯^Ä « %:O(Id¸¡�;þ&¼ùlw®£ _ !É®àáõDy{éˆ¬Ïü5u  º Ä É ¢|üOÏô~Œœùµý	Z	b	e	h	°	RV>bFJÅ  § ø ×M[·2áí‘«Y¿âÝÒ ƒ´ƒ*0;*~�˜Tœ<�‰ñHÈœ µ=Àí2¯‡ÁÕ,^ž˜¥L’ ) £ Í …œ
,¡	$šzI�mèó®E Ÿm¿áÂa*Ò
jöŒòWŽ+2ÜW   öE¾é
þ
´Ì…´r¢ÏÀ›À€
6' E8s˜ö"<AF…ã2áŽ¸ñ¸Xd�ž0]‚•¼&ÓXMnïUvÊ! Ä9¦Ÿt¡µ­ÒHˆ	F	ò	0
�
×
£¾)„Ý˜JIXÂ	…¥] `¶X©ª	

ìÖYçÚ ï òÍeä�,f‘}&ƒÇGå> ˜Ü'¼?Â‘	Ö	Ë:7 \ •ÈX�'-ÞzžÚûRˆú8
O
—
rŽ	–ºzÑéZ¨¶¨ ‹ º.²•"$Ì·	
.î§Þ1R[Ò.S(œÄ8$ 
m©‚ñ÷šûa§§ö	J\‰Sdmq¤sÄ;|øšá”‡”´#> 1FvE’opô#
Qdæ
wØ$h¹Kr“”  — Ž�Eç7	'	û	
§Æ:Ùïà Åßiðäñ0	å	ïGv“Ã;™aÙXàE ½ÇŒï"–©G\ W¬3™t" „ † “ • µïõLCW¥Ò%	.	�	µ	6
=
?
M
•
äïÉçéöø<>…‘l
 ±àB	/a"Â¦š ˆ ·Ùå°ÏÔz	‹ñ;ëúÀd,¥ Ü NA
øû¢×
`Ýý6S/ ÊûYÅuœÏ	ê	4Bká¶Åf¨º¶]˜ å ë ·ÇTfd«&	R	m	r
{
º
Ã
6‚òw±vn@hN÷;n Ú#w•˜	3	9	ìsÆÂüp8ËC].P[Žj¬æ¬! ñ Ï1ÓàÉç)]˜%MZeãjKèñÿ€Ë~Ü\²ƒ × ŽH
z¦wH$Ä €‡ŒÂ		¹¸õò¨^
 + Ÿ †
Î
Û
a‘v— Ï )>SÂ‘52
œ>®³4UÕ0 = A K Û>[7´çM	Ã	ž…Èce j ½„çW	�	¦	º	±Í*‘ü(F E ’&&Û; ¥ |D	`	 
ç
ü
÷kªæ Œ–£x	p
¸
4-9XZÀ"I²í
 Ž�K	� œ½.   H Y u ?õ.!	6	>	Ó	0VØ ‚ê  o cPŠÒKiÆädo‘ÞŸ . P ª 'cÝTÀw]LÞêv£°ž¿ ~ ¡{³‹ø´ì¯	QôS¾�áÎðG ( ¢ ´lÁ¿1®Ë‹1‘ÛV ñD_rž!;â¬
½c|ƒÜ—ÒÙWÁT [ Š ¨¹Û,úùÕ	
q�í0Ñ-"§  0EÄðÅvØ:˜`ßD ’ KÑ$	-	A	÷õcü5„.� ÆÈ(úc›8	l	Î	�jru7g�±: 1
G
…
Í
² J Ú{_	œ	°Çû    t  	=	J	w	/3×Yhãc�Ýì ' } C^³ÊóàÑuVÀSU ‘ Çø#	,	@	Í	p€iôbf—Ðû4�Þ  s B0	<	v	›	.2¯ÖgúT$  	 w Ž � � u	˜	™	š	)*+,-mnoÚñòó@A^_`ažÏùmŽS 
 x û �Ð|	ÍdÛB åþŸ„ynYd' o|A¹ãòm©Ñè97ÖØÜl2;ø=Žôü´í+#…‰µj­¸ü)e  y ÏçÔUž²×q	}	ƒ	œeÜ"Oìì¼JZ ü  5JîÌ÷6ÜÔ; 
�“ÎN^adæÿÕ Nù ¡§Á¥Eß		X4Ž”C¡ÂzÇo r}ªënªÒÇú”3<Kù>Ë4­µî$®ïýf › \œøRpóéL™8Ù¿	ŒÔÝ)�õjªýi*"  ¯<Bºä×Ûqt›×ê±æMt±³(q†Š£¶U™§ª¹‹ö =:mºD1mý‡8CGP˜¤,“k1 ! -V�‚~	„	C
‰
Ñ
�µ!HÕ,ÈïuP²duÆÿüK  6 µ e`Õó¬�
É
%²#Ñp‹à½Ñ‚ z Ðèx„‡ŠZzÝIl–Ør	ÑfÁÝkÕ5Yéì¯ #8MŸ³â>¶œÍ`	Âí¬í¡Ûã[ ‚ ÿ kÈÝè	
!
IO”b´å	ª1|Â ï	²À­	O�Ú¶¡G» q Íkø7Õ5Ý	‘\_ÔbeŒtÖ8œêQ¯ú8HQ 2 4 ¯ ý !6KZG”<
Ç
ÏÎ»ç ‰sO ¯Pµ]
É	à	ë
 
¤15�MÃßf>8{ap ± ¢¨¦YÐíæD0{�>B$  ]Œ 1•½”ö+ Þ Â}FJV
_
ž
§
Þ
ó
‚ÙyÙœ¢¯é�È R ÿøÓw?È6=_?&@ï¥×Áðþg	 «$(
û#KÕ% ±ì4�É5¾7®ÃØàh‚ÈX¯Î)5 sv5~Ðo¥«ÌtÂOs£²ãH]ó)AbƒÍÑ )•.4Lúg—¨Ìí,b}‡ƒ¶¼ì@9ñx ¶) ]Shq¼ÙëêhR…ÇÍ`�ÞMÚ?Õ˜¡ÜN�Ÿ¸k«¿Z»á{ À ùé±†Ý¾Ð3þD» }Ÿ œ uRWÀ	�ùpy²ø+$ �Gšßôc�MVòšµ9QT¼Þêšô*ö_w“j†ÅVŒ£š °×Cd»å“Ø˜_ÜuœØ5_‘ ç´ö¤·Všr	 =3Ñ	¬$Vu(c zyË	ÃÈ²5>ž)MÅ‡ê«ºŒ÷b  0 :[r°ë²2hNr‹¡¨W¹ aMÇº'½—™>3xßè'Ì e J>Cýþlì	Ç!9PÈTúz=Ñ†+ ¬ &;P$“H‡¹å;¢‘ÕÚ	â	ºDZtˆD›‰‘™¥ªm¸Îû-ZO¯¤22 é)>en|·×»<Eiºÿ2_wž¤á
í
ö
EŸfn¿þm¦ã!”H„QOá_”:lÎ " ` í ¡¯º¯Z{§	…	Z
f
‘
¢
®
|ðü!‰š­Çv ô ,AV…vÊÞj
²
8[âŒ‚ßêv¶Ðq|  â ÉW n	D
áô¶"PEIŒ)ý³PZeDoùØ&A: ¤æ¹ý".2�ÿqƒÔJ¯«¡î	2
c
Š
«
Ò
Àqžö+©ý«Ö#Rz-†ÉQ� n6vÎÓ ËýAL_# 7 ç fzI”-P†õ�ú½ö ,[	¢	ÃÒD³	q2jŒÒ‡§z# ¶ » Å Ê Ò Ò£Vh}ªýž�ôþ±	t
¼
„S&?ÒcCGá?p~ˆ  g ¬T	i	‚
Ê
ÊÖK aÖr_Ð(0¶­	c	f	�
Õ
W Wð€$p}¾ƒÆ! ÆÑ%‹¯[®ÞgmŠn†âô	y
Á
¥}ïxÀÂElÖÞ6Z
 ¨ NyÙ
¬F�èÓ  { ù Øì\Å›ÚîH	o	s	9gpÞ‹) € ³ ;¨é+…ˆi{J³—¸Ù3}
Å
ñ
Ò€’³IZšÉã^Ä@—_êíO $9N£·f?‘
BŠÃ¢� L)­	U;=èaÜIÑ „õ+D<Ñ™iy†V�Î—¤òK­D5 Ã87µÌ@E„ ´¨ã1+e�ñ	¢·�æ/LîmîäÉ=\   	l-�»!ú>¦Áy[ˆ¹-clp£Ðr:§6™¦Q“Ã œ
ÆÞæïîä	ú	
"
!P•îF¨uÂ
ŸV«2˜ ƒ Û ¶äôV5
îúÈÖæ	_¿Ü;R) SÉª"%LdÄit”—Q	é	J3Av°çëµÄþe§¹Ê\
M}-O« * Î (=R†Á	y›·ôñ] ¤  =Zæ³æ
û
%�åE ‹•‰ô-¢5	U,8JŽn�H¼  ð&b
q�:À«¿vŠ¾ ®	
¼P\{‚Š½ÛÍéï¢¯0�F §ÅJÃùb+š
tu×9,_°9 ~XÐb�¿R  r AÏ	;	l~Õfäý–�ø3lÝRX.  nÎ¦¸ÀÓâñl¨ç58¤ÓÖ6D×Þ	
’Mk1÷]`�ó!3c�“ì"ë·ûI  [q›÷‹é†°åFs—£¬²¦# 5 "7L_ŽÜH�•=€
È
µÐ ±›ÌÐoŠ±Át4�è® 3 ® þ F“¿¬	Ü	
HNÍÙµ‹º7ÁP®7 ° I^
¦
ê
ÿ
ÏØ0L®¼è/œ=  °4Ï÷#3â>G\òaÐ–§+J†½6‚Ôg�?ðÖwµ% Fgt™êQ€è„P�L>°…Ü ÏÛó2ž^v…ÄUo÷| Ö9—^4Ê	�Ÿ#1U'L Vbq7 d =BG`†ä~¶hk¹^¹Ôá	à
ì
õ
D¹Ye¥  ƒ–ÇS�2NÍàYN<Þç9&Ë…2 á ó £åü1 up®¹ÓIª®z ¦1
Y
b
�
¡
ª
Z¿p*O¨Þ‹( ™YÍ
CnÊ%@^ yÑ©,�/¼ÂÑCV1|†¦" ² Åë:§ÄhšÙf‰mG	ó	Ø
ð
¤8o|îEŽÃ?Šç^ Âô6Ë¢¶(§	¡h…åç–£KJÐ4 ,ã	Åùî!Kh“ù	í§êùZ¸	kÏU¦¾ÉÛ—, a9Yª½åå
ú
x¼äð€  @·
 2ãëa!•÷ p^�H«	
GM×è¯ä–±<
 3ÕÎé_çƒOgKß
ô
¯„ÛÚ�„KT€Ÿö´" à äóû5Ã+g'e.lyX
a
 
©
ï
~Á7B{Š'ÌÉæ3? +â8Gg’ä
ù
·j®T¥°Èê! ß úf~åæd‚-W
`
Ÿ
¨
ã
ø
ƒÚAzQRS£¤HIJžËôõ  .b  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                           0                                                                                                                                                         
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               3                                            	                                                        
                        	                                                      %            	                  	      I            	                                                                                    $                      7         (   $      $   0      !   ™   G         	      !      Y                                                                                                                                                                      0                                                                         
                                                                                                                                                                                                                                                                                                                           3                	                    
        	                    %    	      	  I    	                            $        7   ( $  $ 0  ! ™ G   	  !  Y   jÏ  kß  kù  l/  p•  uS  {¡:½`k<Õg�äpåæG  2'Íä›šVµKi
±
 ÇbQöþ£Cƒ~:DWàoH@‚Á	‚Á	s
»
Ñ o’»g¥óüýLQZ‰=–Ð	s
»
î
=C"Co—¾-§f™ý%|�Â4p;ÝàªJ˜

¨i›š›šL›ši€ Ñé…µgãK6�,Y
¡
 ¸ nyj8hÎXje8®ì �€�YœÛ	ŠèT�
à>ÈàáªÝ�èFJ	u¸€›ûê	Åì   j}Ùï /6Þ–#zác-~k~p€À
vš§ÍÑLS¤sÄ9‡#8)	ÊæIz:ý·"‘r‡^2¼) ÙAÎ?å?[éƒKÚ�á>xü'<Qá0ßæ$>?š§S‡Æ	á>š ¾	få²zúÑax
À
Ößiðaà=Àà Š'?ÍMç"‘zÕ¢Ø	�r’‡ùWhï á /6Þø–#zbácÆ	\
¤
>?'-~#JkÉòÅu5 ±oŠ]pÅ+ ,¢—¹^„>Lyó	X
 
>xÂC·Ûj¥&	n	¯"2¼5ÓfÕp‹2áF[ñ`Ï•¦*…¼�ïv˜ëîTeÍÑ9äûa
©
ÌÉº5ê ¶ªvôÍÑ5“®V90 Åó	á0ßæÙ$AÎ>?å±lÕ›Å,ó	xÂCÜ	‹è~'<Q
€Ä0^oQ¥FJ[_f© Y`™ŸÏe
x
­
À
oé§os•¢¦·*Eq…˜�¾9iyÅ¢—^ó	&z^	®­x
À
¿WhZÆ	†‘çó!;¸	OK&›	¯ú&
!µë
 
¤Mß8aæIc
«
�n"”ëO8z
Â
z^	{W²±&DzÝ�Ù^	`¸R€èŽ?'ë›ZepBºlJÀYÔÙœ¶îtÖ8‹Õ¶Uïi	Ã{ùùŒ¦F[`Ï•¦*…�q¯á	2
+#zYN6Ë&f=
q[M2
5 [±ouŠ F —�\ä=4­Ü?  j±/Q�}ÙD	
SÀ¶¬©Æ	Ò†ç[Ç	w<’ô", ®¹ù®z¦Y
�
¡
Z¸kÏ ™¦1 ¸Rþ©$cÃs–P	í	@uæü~ªÃý"Qd…¦¸[œŸmÒN@ªáâøbß5>?Ì/h([ˆÉò)3Î÷>€Ö´�8Ÿ³â¶ííã[ß/[)¸þí	ü~ª"Q…œŸmÒ@R©$cÃs–P	@uæÃýd¦¸[Nª² :§hð
Ã?^H”¤Á¢@ìaëŸ–3"Tc u¸RËþs}Nr©±$cjÃ(]s‚–¸ÌÓP	í	C(@uæ-üf~ªÃý"Qd|ÆR…¦¸»1Ì[œŸm8;ÒÝæN%@ª„,3 Î÷®¹ù>®z¦Y
�
¡
Z¸kÏ ™¦€Ö´*²|
Ä
²H™È]–NÍX1	ðÄúÚYhª=À‡,˜¥’á O‹(YCn%@
©{³ñ
€š@_Ž� ±t"
P ùîÃAÂÝ U
�
Ý
Øµ8€à�žÕD0^ß&üU~Ž=Z�³"
P �±tâ 	á³PZeo<†�—¤KH:ý%»k­Zg¸_gß
ô
v5^%?˜ S½ÄŽ„¡ìxš³ó	G:9QTrö2_hNj¡¨ªPÝ
!
O”ú1uÃ$ª1{·
 2ë!Þê“#Œ& ¼²C	Éòj©UÚsÊúè¨Ñ÷�!~ðÍk7Õ5Ý	‘\_bŒêúHÄx½„¡š	¼Ús˜ SŽì³óc uËs}Nr±j(]‚¸ÌÓC(-f|ÆR»1Ì8;Ýæ%„â <	á†�—¤³KPZeo�¦îy Ïç×q	eÜ]É	apaMÇº'½—™>3xßè'Ìd =BG`†ä~¶hk¹^¹Ôá	à
ì
õ
D¹Ye¥  ƒ–ÇS�2NÍàYN<Þç9&Ë…uËsvNr±È(‚Ì'
"(5-^f%|?»Â×ÇW8Í(- O ¡ ³k²Ü áS0bRKŽ~Ú|™¥‰Ãþoïò 3TbÂrO	
3
S‰?å¯6¡×.Ê¬45Mþ©è#’ü{ÖýLÆv�£Ù	ë	žCs¾lâ“ÆO˜š=ˆ©·ú^yÐÍ* Î (=R†Á	y›·ôñ]Xi­[v‚xÆkàjñ™/ªÇ	æ	wÓ<‡’šèôbqzªá"Fb nwâø•›ÃbI¨\·ÎÒ÷	<Bv5?MÍTh¥Í)tˆÅ0â:•Éòˆ$°4Ï÷#3â>G\òaÐ–§+J†½6‚Ôg�?ðÖwµÆÑ%‹¯[®ÞgmŠn†âô	y
Á
¥}ïxÀÂElÖÞ6Zb Ù nw|™¥Àâ‰šÃòøþ/3Qo¤Ñï6¦¾Íò 3•›½Ã÷Tbtˆ¤¨äìþ	Ib¨¬ÂB\r·ÎÒO	÷	
3
\
¤
<BSjv|‰­	*?K¥å÷/5?M¯µÍ6Thnr¡¥¬ºÍ×â)SctˆÅ.·Ê0J¬49R¡âí5:•½ÉåòMˆµÔþ$©1¨ Ž�ÆNŒ–Ñ%y‹¯[®ÞgmŠ£n†âK	x	ô	p
y
¸
Á
Ù
4¥-¬}ï9xÀXÂEZlF�ÀÖ "�I²Þèí6Zœ½Ó.°/ cx¯^Äå ë ·ÇTfd«&	R	m	r
{
º
Ã
6‚òw±vn@hN÷;n9*	j	ƒ
Ë
'ËþLp^�H«	
GM×è¯ä–±<
U ^‰TëîŠ“†ÈßNT‹	”	
$
:@ehtýÝOl¢x¼iºJ Ú{_	œ	°Çû / M V î |™¥U`‰Ãþco¶ïò 3X‹�©	!Txb°ÂàOr¯O	€	Œ	•	ª	


3
’
S‰ì?^ÖåY¯Þç6P¡×m£§.}Êy¬Ú%4½ 5ÄïMþ©› \œøRpóéL™8Ù¿	ŒÔÝ)�õjªýi*   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="XRE" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="285-347" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;aryl hydrocarbon receptor AhR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;xenobiotic response element (3 copies)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="minP" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="392-423" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;minimal TATA-box promoter with low basal activity&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4044-4092" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="105-153" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="pause site" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="167-258" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA polymerase II transcriptional pause signal from the human&amp;nbsp;Î±2 globin gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="hPEST" directionality="1" translationMW="4153.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2231" maxFusedRunOn="2231" detectionMode="exactProteinMatch"><Segment range="2109-2228" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;PEST degradation sequence from mouse ornithine decarboxylase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="SHGFPPEVEEQAAGTLPMSCAQESGMDRHPAACASARINV"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2280-2401" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2803-2938" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2595-2952" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4419-5007" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5998" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5207-5998" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5999-6067" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="11" name="HygR" directionality="1" translationMW="38445.46" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2983-4020" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MKKPELTATSVEKFLIEKFDSVSDLMQLSEGEESRAFSFDVGGRGYVLRVNSCADGFYKDRYVYRHFASAALPIPEVLDIGEFSESLTYCISRRAQGVTLQDLPETELPAVLQPVAEAMDAIAAADLSQTSGFGPFGPQGIGQYTTWRDFICAIADPHVYHWQTVMDDTVSASVAQALDELMLWAEDCPEVRHLVHADFGSNNVLTDNGRITAVIDWSEAMFGDSQYEVANIFFWRPWLACMEQQTRYFERRHPELAGSPRLRAYMLRIGLDQLYQSLVDGNFDDAAWAQGRCDAIVRSGAGTVGRTQIARRSAAVWTDGCVEVLADSGNRRPSTRPRAKEVGRV*"/></Q></Feature><Feature recentID="12" name="luciferase" directionality="1" translationMW="60645.64" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2231" maxFusedRunOn="2231"><Segment range="456-2105" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic &lt;i&gt;luc2&lt;/i&gt; version of the luciferase gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVDITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMGISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKIAV"/></Q></Feature></Features>
  Õ<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="15" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="RVprimer4" sequence="GACGATAGTCATGCCCCGCG" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="4158-4177" boundStrand="1" annealedBases="GACGATAGTCATGCCCCGCG" meltingTemperature="62"><Component hybridizedRange="4158-4177" bases="GACGATAGTCATGCCCCGCG"/></BindingSite><BindingSite simplified="1" location="4158-4177" boundStrand="1" annealedBases="GACGATAGTCATGCCCCGCG" meltingTemperature="62"><Component hybridizedRange="4158-4177" bases="GACGATAGTCATGCCCCGCG"/></BindingSite></Primer><Primer recentID="1" name="RVprimer3" sequence="CTAGCAAAATAGGCTGTCCC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="206-225" boundStrand="0" annealedBases="CTAGCAAAATAGGCTGTCCC" meltingTemperature="54"><Component hybridizedRange="206-225" bases="CTAGCAAAATAGGCTGTCCC"/></BindingSite><BindingSite simplified="1" location="206-225" boundStrand="0" annealedBases="CTAGCAAAATAGGCTGTCCC" meltingTemperature="54"><Component hybridizedRange="206-225" bases="CTAGCAAAATAGGCTGTCCC"/></BindingSite></Primer></Primers>
  Ì<Notes>
<UUID>dd08692d-c9c9-4b9e-b7cb-a8007487c2f2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pGL4.43[Luc2P XRE Hygro]</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>&lt;html>&lt;body>Vector with a minimal promoter and a xenobiotic response element for studying cell signaling using destabilized luciferase.&lt;/body>&lt;/html></Description>
<Created UTC="5:0:0">2012.7.2</Created>
<LastModified UTC="7:6:23">2025.7.8</LastModified>
<AccessionNumber>JQ858513</AccessionNumber>
<CreatedBy>Promega</CreatedBy>
<Organism>Mammalian Cells</Organism>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>Unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      HO  d                E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
  ²<?xml version="1.0"?><CustomEnzymeSets><CustomEnzymeSet type="1" name="Unique Cutters + BglI, SfiI" enzymeNames="AanI AarI Acc65I AlwNI ApaLI AvrII BamHI BbvCI BciVI BfuAI BglI BlpI BpmI BsaAI BsmBI BspMI BsrGI BssHII BstBI BstEII BstXI BstZ17I Bsu36I DraIII Eco53kI EcoRI EcoRV FseI HindIII KasI KpnI MfeI MreI NarI NotI PaeR7I PciI PluTI PmeI PsiI PstI PvuI SacI SacII SalI SfiI SfoI SgrAI SpeI StuI XhoI XmnI"/></CustomEnzymeSets>
